Miconazole(mi kon' a zole) | Monistat |
| Category | anti-inflammatory |
| Parameter |
Effect |
Result on hair growth |
| DHT |  | GOOD |
| 5a-reductases |  | UNKNOWN |
| PGD2 | | UNKNOWN |
| PGE2 | | UNKNOWN |
| PGF2 | | UNKNOWN |
| CRTH2 | | UNKNOWN |
Where to buy
 
|
A generic version containing Miconazole. There are many reports of increased hair growth from the use of Miconazole.
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Miconazole
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Information
| Description |
Miconazole is an antifungal agent used to treat various skin conditions. User report increased hair growth and thickness. It
is thought to interfere with DHT much like Ketoconasole.
|
| Typical Results |
Moderate to excellent regrowth.
|
| Typical Dosages |
Topical 2% used daily on the scalp.
|
| Significant Side Effects |
Scalp irritation.
|
| Pharmacology Pharmacodynamics |
Miconazole is an antifungal.
Mechanism of Action
Miconazole inhibits the enzyme cytochrome P450 14α-demethylase which leads to inhibition of ergosterol synthesis, an essential component of the fungal cell membrane. Miconazole also affects the synthesis of triglycerides and fatty acids and inhibits oxidative and peroxidative enzymes, increasing the amount of reactive oxygen species within the cell.
Activity in vitro and in vivo
Miconazole is active against Candida albicans, C. parapsilosis, and C. tropicalis. Correlation between minimum inhibitory concentration (MIC) results in vitro and clinical outcome has yet to be established.
Drug Resistance
In vitro studies have shown that some Candida strains that demonstrate reduced susceptibility to one antifungal azole may also exhibit reduced susceptibility to other azoles suggesting cross-resistance.
Clinically relevant resistance to systemically utilized triazoles may occur in Candida species. Resistance may occur by multiple mechanisms such as changes in amino acids and/or in the regulation of the target enzyme and of a variety of efflux pump proteins. Multiple mechanisms may co-exist in the same isolate. Resistance breakpoints, correlating in vitro activity with clinical efficacy, have not been established for miconazole.
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